Add the flour, oregano, garlic powder, chili powder, and kosher salt to a bowl and stir to combine. Pour it onto a plate.
In a bowl, stir together the lime juice and olive oil.
Add 1/2 cup panko to a plate. Set up an assembly line with the plate of flour, then bowl of oil, then plate of panko.
Cut the avocado into slices about 3/4-inch thick (you’ll get about 16 total).
Dredge each slice in the flour. Then dip it in the olive oil mixture and tap off excess into the bowl. Gently press it into the panko to coat it well. Lay the slice on a parchment lined baking sheet. Repeat for all the slices. When the panko starts to get gummy, refresh it with the remaining 1/2 cup dry panko.
Bake 12 to 15 minutes until golden. Serve warm, with a dipping sauce as desired (see above for ideas).